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Predmet će proširiti znanje o osnovama animalnih modela, ponašanju životinja i odgovoru na stres. Predmet će pojasniti koje se vrste animalnih modela koriste kao pokazatelji određenih psihijatrijskih poremećaja i kakve se sve životinje mogu koristiti u animalnim modelima. Predmet će pomoći razumijevanju biološke podloge psihijatrijskih poremećaja, I značaj gena u psihijatrijskim poremećajima. Predmet će uputiti na koristi ali i štetnosti uporabe određenih animalnih modela.

Uvodno predavanje o animalnim modelima, Animalni modeli anksioznosti, straha i depresije, Animalni modeli shizofrenije i manije, Animalni modeli PTSP-a i ADHD-a; Vježbe: test forsiranog plivanja; rotarot test; Animalni modeli alkoholizma i neurodegeneracija; Prikaz biokemijskih i genetičkih metoda koje određuju pokazatelje iz bioloških materijala; statistička obrada podataka;

Prikaz znanstvenih preglednih radova iz područja  animalnih modela psihijatrijskih poremećaja.

• Belzung C, Lemoine M. Criteria of validity for animal models of psychiatric disorders: focus on anxiety disorders and depression. Biol Mood Anxiety Disord. 2011; 1:9  doi:10.1186/2045-5380-1-9.
• Davis BA, Isles AR. Modelling the genetic contribution to mental illness: a timely end for the psychiatric rodent? Eur J Neurosci. 2014; 39: 1933–1942.
• Donaldson ZR, Hen R. From psychiatric disorders to animal models: a bidirectional and dimensional approach. Biol Psychiatry. 2015; 77:15-21
• Edwards S, Koob GK. Experimental Psychiatric Illness and Drug Abuse Models: From Human to Animal, an Overview. Methods Mol Biol. 2012; 829: 31–48.
• Mitchell KJ, Huang ZJ, Moghaddam B, Sawa A. Following the genes: a framework for animal modeling of psychiatric disorders.  BMC Biology. 2011; 9:76  doi:10.1186/1741-7007-9-76.
• Molet J, Maras PM, Avishai-Eliner S, Baram TZ. Naturalistic rodent models of chronic early-life stress. Dev Psychobiol. 2014; 56:1675-88.
• Nestler EJ, Hyman SE. Animal models of neuropsychiatric disorders. Nat Neurosci. 2010; 13:1161-1169.
• Salgado JV, Sandner G. A critical overview of animal models of psychiatric disorders: challenges and perspectives. Rev Brasileira Psiquiatr. 2013;35:S77–S81.
• Schmidt U, Keck ME, Buell DR. miRNAs and other non-coding RNAs in posttraumatic stress disorder: A systematic review of clinical and animal studies. J Psychiatr Res 2015; 65:1-8.
• Wang HN, Bai YH, Chen YC, Zhang RG, Wang HH, Zhang YH, Gan JL, Peng ZW, Tan QR. Repetitive transcranial magnetic stimulation ameliorates anxiety-like behavior and impaired sensorimotor gating in a rat model of post-traumatic stress disorder. PLoS One. 2015; 6;10(2):e0117189.
• Yadid G, Nakash R, Deri i, Tamar G, Kinor N, Gispan I, Zangen A. Elucidation of the neurobiology of depression. Insights from a novel genetic model. Progress Neurobiol. 2000;62:353-378.
• Norman TR, McGrath C. Stress induced animal models of depression. Stress Med. 2000; 16:195-197.
• Willner P. Stress and depression: insights from animal models. Stress Med. 1997;13:229-233.
• Nestler EJ, Gould E, Manji H, Bucan M, Duman RS, Gershenfeld HK, Hen R, Koester S, Lederhendler i, Meany MJ, Robbins T, Winsky L, Zaloman S. Preclinical models: status of basic research in depression. Biol Psychiatry. 2002; 52:503-528.
• Russo-Neustadt A, Ha T, Ramirez R, Kesslak P.  Physical activity-antidepressant treatment combination. Impact on brain-derived neurotrophic factor and behavior in an animal model. Behav Brain Res. 2001; 120: 87-95
• Pardon MC, Gould GG, Garcia A, Phillips L, Cook C, Miller SA, Mason PA, Morilak DA. Stress reactivity of the brain noradrenergic system in three rat strains differing in their neuroendocrine and behavioral response to stress. Implications for susceptibility to stress-related neuropsychiatric disorders. Neuroscience. 2002; 115: 229-242.
• Cryan JF, Markau A, Irwin Lucki. Assesing antidepressant activity in rodents. Recent developments and future needs. Trends Pharmacol Sci. 2002;23: 238-245.

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